![]() ![]() Immediate-release orally-disintegrating tablet: Evekeo ODT: Median time d-amphetamine and l-amphetamine 3.5 hours (with water) and 3 hours (without water) increased with food in adultsĮxtended-release orally-disintegrating tablet: Adzenys XR-ODT: Median time d-amphetamine 5 hours (7 hours with food) and l-amphetamine ~5.25 hours (7.75 hours with food)Īdzenys ER suspension: d-amphetamine and l-amphetamine: 5 hours (median) with or without foodĬhildren: Median time d-amphetamine 3.9 hours and l-amphetamine 4.5 hoursĪdults: 4 (2 to 7) hours Duration of Action Immediate-release tablet: Within 4 hours (de la Torre 2004) Urine (30% to 40% unchanged ~50% as metabolites) Time to Peak Hepatic via oxidation, deamination, and CYP2D6 Excretion Oral: Immediate-release tablet: V d: 3 to 4 L/kg (de la Torre 2004) Metabolism Immediate-release orally-disintegrating tablet: Evekeo ODT: C max and AUC comparable to equivalent immediate-release dose Distribution Immediate-release tablet: Rapid (de la Torre 2004) Pharmacokinetics/Pharmacodynamics Absorption The anorexigenic effect is probably secondary to the CNS-stimulating effect the site of action is probably the hypothalamic feeding center. A less significant mechanism may include their ability to block the reuptake of catecholamines by competitive inhibition. Tablet Extended Release Disintegrating, Oral, as base:Īdzenys XR-ODT: 3.1 mg, 6.3 mg, 9.4 mg, 12.5 mg, 15.7 mg, 18.8 mg Pharmacology Mechanism of ActionĪmphetamines are noncatecholamine sympathomimetic amines that promote release of catecholamines (primarily dopamine and norepinephrine) from their storage sites in the presynaptic nerve terminals. ![]() Suspension Extended Release, Oral, as base:ĭyanavel XR: 2.5 mg/mL (464 mL) Įvekeo: 10 mg Įvekeo: 10 mg = Discontinued productĪdzenys ER: 1.25 mg/mL (450 mL) ![]() Excipient information presented when available (limited, particularly for generics) consult specific product labeling. ![]()
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